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Reaction id: 0210091013_18, verified by Personal Chemistry ©
1298
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86
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Piperidine
Acetic acid
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EtOH
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P18
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Yield: 90% Time: 1500s Temperature: 180 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 7570458 |
223.275 |
1.000 |
0.500 |
111.637 mg |
| 105566 |
113.116 |
1.063 |
0.600 |
63.847 µl |
| Piperidine (0.5M in THF) |
85.150 |
1.000 |
0.100 |
200.000 µl |
| Acetic acid (0.5M in THF) |
60.052 |
1.000 |
0.100 |
200.000 µl |
| EtOH |
46.069 |
1.000 |
45.584 |
2100.000 µl |
| Product 1 |
318.376 |
1.000 |
0.500 |
159.188 mg |
Keywords
Knoevenagel Condensation
Comments
Synthesis: The reaction was also performed with DMF as solvent at the same temp./time conditions, but then the reaction mixture contained more impurities.
Work up: The product precipitated after the reaction as yellow crystals. The crystals was filtered off, washed with cold ethanol and dried.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Kuster, G.J.; Scheeren, H.W., Tetrahedron Lett. (2000), 515-519
Analysis
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0210091013_18A.pdf