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Reaction id: 0210151015_05, verified by Personal Chemistry ©
CARBOMETHOXYMETH...
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2-CHLORO-3-QUINO...
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NaOMe
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MeOH
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P5
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Yield: 57% Time: 600s Temperature: 120 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 1779584 |
415.272 |
1.000 |
0.800 |
332.218 mg |
| 73568259 |
191.617 |
1.000 |
0.400 |
76.647 mg |
| NaOMe |
54.024 |
1.000 |
1.000 |
54.024 mg |
| MeOH |
32.042 |
0.787 |
54.035 |
2200.000 µl |
| Product 1 |
247.681 |
1.000 |
0.400 |
99.072 mg |
Keywords
Condensation, Wittig Olefin Synthesis
Comments
Synthesis: Higher temperature did not improve the purity. The outcome of the reaction was poorer with indole-3-carboxaldehyde. It was much less succesful when using triphenylphosphonium bromide as Wittig salt.
Work-up: After completed microwave irradiation, a white precipitation was formed in the vial. This was filtered off and washed with cold methanol. No further purification was performed prior to the NMR experiment.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Westman, J. Org. Lett. 2001, 23, 3745-3747
Analysis
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0210151015_05A.pdf