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Reaction id: 0211071022_05, verified by Personal Chemistry ©
Yield: N/A Time: 300s Temperature: 120 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 500221 |
107.112 |
1.135 |
0.200 |
18.874 µl |
| 603350 |
262.292 |
1.000 |
0.500 |
131.146 mg |
| 590170 |
119.954 |
1.722 |
0.500 |
34.830 µl |
| K2CO3 |
138.204 |
1.000 |
0.800 |
110.563 mg |
| MeOH |
32.042 |
0.791 |
17.394 |
704.587 µl |
| Product 1 |
130.150 |
1.000 |
0.200 |
26.030 mg |
Keywords
Cascade reaction, Condensation, Multicomponent, Wittig Olefin Synthesis
Comments
Synthesis: Higher temperature resulted in more impurities and less product for the reaction between triphenylphosphine, nicotine aldehyde and methyl bromoacetate. The conversion is supposed to be much higher than the purity value indicates as triphenylphosphine is used in excess. Quite a lot of the stabilized wittig ylide was formed (Mw = 301.33).
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Westman, J. Org. Lett. 2001, 23, 3745-3747
Analysis
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0211071022_05A.pdf