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Reaction id: 0211071022_27, verified by Personal Chemistry ©
1505
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250
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810
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K2CO3
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MeOH
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27
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Yield: N/A Time: 300s Temperature: 120 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 22042791 |
200.241 |
1.000 |
0.200 |
40.048 mg |
| 603350 |
262.292 |
1.000 |
0.500 |
131.146 mg |
| 96322 |
152.980 |
1.616 |
0.500 |
47.333 µl |
| K2CO3 |
138.204 |
1.000 |
0.800 |
110.563 mg |
| MeOH |
32.042 |
0.791 |
16.562 |
670.910 µl |
| Product 1 |
256.305 |
1.000 |
0.200 |
51.261 mg |
Keywords
Cascade reaction, Condensation, Multicomponent, Wittig Olefin Synthesis
Comments
Synthesis: Higher temperature resulted in more impurities and less product for the reaction between triphenylphosphine, nicotine aldehyde and methyl bromoacetate. The conversion is supposed to be much higher than the purity value indicates as triphenylphosphine is used in excess.
Analysis: Two diastereomers are formed, one in large majority.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Westman, J. Org. Lett. 2001, 23, 3745-3747
Analysis
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0211071022_27A.pdf