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Reaction id: 0200011008_03, verified by Personal Chemistry ©
4-Bromobenzonitrile
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4-Borono-D-pheny...
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Na2CO3
Pd(PPh3)2Cl2
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MeCN
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Product 3
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Yield: 84% Time: 300s Temperature: 150 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 623007 |
182.025 |
1.000 |
0.500 |
91.013 mg |
| 90580646 |
209.009 |
1.000 |
0.500 |
104.505 mg |
| Pd(PPh3)2Cl2 |
701.890 |
1.000 |
0.025 |
17.547 mg |
| Na2CO3 (1.0M in water) |
105.988 |
1.000 |
1.000 |
1000.000 µl |
| MeCN |
41.053 |
0.780 |
19.000 |
1000.000 µl |
| Product 1 |
266.300 |
1.000 |
0.000 |
0.000 mg |
Keywords
Aryl-aryl coupling, Catalysis, Suzuki Coupling
Comments
Synthesis: The reaction mixture was degassed under vacuum before subjected to microwave heating. The reaction proceeds with retention of stereochemistry, as showed in reactions 0200011008_11,12 and 13.
Work-up and purification: The solvent of the crude reaction mixture was evaporated and redissolved in methanol acidified with TFA. The acid solution was purified by RPLC eluted with 0.1% TFA in a H2O/MeCN gradient. The product was obtained as a TFA salt.
Characterisation: The product was characterised by NMR and MS.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Gong, Y.; He, W. Org. Lett. 2002, 4, 3803-3805
Analysis
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