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Reaction id: 0210091039_04, verified by Personal Chemistry ©
1506
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1440
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product 4
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Yield: N/A Time: 1200s Temperature: 200 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 533686 |
195.061 |
1.321 |
3.048 |
450.000 µl |
| 122521 |
166.157 |
0.969 |
12.189 |
2090.000 µl |
| Product 1 |
252.247 |
1.000 |
0.000 |
0.000 µl |
Keywords
Arbuzov reaction, Substitution
Comments
Synthesis: Temperature and reaction time used in this reaction is a suitable method for slow reactive primary bromides and iodides. It can also be used on reactive secondary bromides.
Purification: Excess of triethylphosphite and ethyl diethylphosphonate are removed after reaction using vacuum distillation (triethylphosphite 50°C-55°C and ethyl diethylphosphonate 70°C-75°C at 10-15 mbar). For this substrate no further purification was made. Crude NMR confirmed the structure of the product. It is recommended to purify the product on a silica column.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Bhattacharya, A. K.; Thyagarajan, G. Chem. Rev. 1981, 81, 415
Arbuzov, B. A. Pure Appl. Chem. 1964, 9, 307
Analysis
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0210091039_04G.pdf