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Reaction id: 0108311010_05, verified by Personal Chemistry ©
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Na2CO3
Pd(PPh3)2Cl2
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DME:H2O:EtOH 7:3:2
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Yield: 97% Time: 120s Temperature: 140 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 78887395 |
178.983 |
1.000 |
0.500 |
89.492 mg |
| 618893 |
215.051 |
1.000 |
0.600 |
129.031 mg |
| Na2CO3 (2.0M in H2O) |
105.988 |
1.000 |
0.750 |
375.000 µl |
| Pd(PPh3)2Cl2 |
701.890 |
1.000 |
0.010 |
7.019 mg |
| DME:H2O:EtOH 7:3:2 |
0.000 |
1.000 |
0.000 |
2125.000 µl |
| Product 1 |
269.300 |
1.000 |
0.500 |
134.650 mg |
Keywords
Aryl-aryl coupling, Catalysis, Suzuki Coupling, C-C coupling
Comments
Synthesis: These conditions gave somewhat higher yield than with ethanol as solvent and triethylamine as base at 150°C for 300s.
Purification: Preparative RP-LCMS.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Brandao, M. A. F.; Braga de Olivieira, A.; Sneckus, V. Tetrahedron Lett 1993, 34 (15), 2437-2440
Analysis
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0108311010_05A.pdf