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Reaction id: 0108091018_04, verified by Personal Chemistry ©
4-Bromobenzonitrile
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Alkene 3
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Pd(OAc)2
P(o-Tol)3
DIEA
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DMF
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2
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Yield: 78% Time: 420s Temperature: 220 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 623007 |
182.025 |
1.000 |
0.360 |
65.529 mg |
| 1759280 |
125.193 |
1.093 |
0.300 |
34.362 µl |
| Pd(OAc)2 |
224.488 |
1.000 |
0.012 |
2.694 mg |
| P(o-Tol)3 |
304.373 |
1.000 |
0.030 |
9.131 mg |
| DIEA |
129.247 |
0.742 |
0.360 |
62.707 µl |
| DMF |
73.095 |
1.000 |
32.432 |
2370.620 µl |
| Product 1 |
226.301 |
1.000 |
0.000 |
0.000 mg |
Keywords
Catalysis, Heck Coupling, Vinylation
Comments
Work-up and purification: Reaction mixture diluted with MeCN and filtered (5µ PTFE filter) before isolation by preparative RPLC.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Crisp, G. Chemical Society Reviews 1998, 27, 427-436
de Maijere, A.; Meyer, F.E. Angew. Chem Int. Ed. Eng. 1994, 33, 2379-2411
Cabri, W; Candiani, I. Acc. Chem. Res. 1995, 38, 2-7
Analysis
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0108091018_04A.pdf