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Reaction id: 0208121012_14, verified by Personal Chemistry ©
1328
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492
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Ethanol
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P2
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Yield: 85% Time: 300s Temperature: 180 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 350469 |
141.101 |
1.000 |
0.400 |
56.440 mg |
| 110894 |
85.150 |
0.869 |
0.800 |
78.389 µl |
| Ethanol |
46.069 |
1.000 |
10.853 |
500.000 µl |
| Product 1 |
206.245 |
1.000 |
0.000 |
0.000 mg |
Keywords
N-Arylation, Nucleophilic aromatic substitution
Comments
Synthesis: Running the reaction in NMP at 180°C for 300 s yielded 86% product according to LCMS. Running the reaction in MeOH at 140°C for 300 s yielded 81% product according to LCMS. Running the reaction in n-BuOH at 200°C for 300 s yielded 96% product according to LCMS.
Work-up and purification: After removing the solvent from the reaction mixture, the residue was purified by chromatography on silica, ethyl acetate:heptane, 1:2, giving a yellow solid.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Hepperle, M.; Eckert, J.; Gala, D. Tetrahedron Lett. 1999, 40 (31), 5655-5659
Analysis
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0208121012_14A.pdf