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Reaction id: 0209041011_16, verified by Personal Chemistry ©
1484
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Oxone
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Water
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1484_23
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Yield: 77% Time: 300s Temperature: 120 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 54965218 |
265.335 |
1.000 |
0.300 |
79.601 mg |
| Oxone |
614.752 |
1.000 |
0.450 |
276.638 mg |
| Water |
18.015 |
1.000 |
116.570 |
2100.000 µl |
| Product 1 |
297.333 |
1.000 |
0.300 |
89.200 µl |
Keywords
Oxidation
Comments
Synthesis: This synthesis was most successful when the chemicals were dispensed manually and water added just before the heating of the reaction mixture. When a stock solution of oxone was used, less product was formed. This could be due to the fact that the oxone salt may decompose when in contact with moisture or water, according to its MSDS protocol, section 10. In there it also says that heating above 50 °C is to be avoided. Attempts were also made to synthesize the correspodning sulfoxide, but they failed. Either no reaction occurred or the sulfone was formed.
Work up: The solid formed in the reaction was filtered off and washed with ca 10 ml of water.
Characterisation: There is a reference spectrum on albendazole included in the 1H NMR file.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Hajipour, A. R. Indian J. Chem., Sect B: Org. Chem. Incl. Med. Chem. 1997, 36, 1069-1070
Schwartz, T. M.; Bundy, G. L. Bioorg Med Chem Lett. 1997, 7, 399-402
Analysis
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0209041011_16A.pdf