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Reaction id: 0210071015_16, verified by Personal Chemistry ©
12
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932
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1009
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1513
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Acetic acid
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P16
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Yield: N/A Time: 300s Temperature: 180 °C
Chemicals
| Name |
MW [g/mol] |
Density [g/ml] |
Amount [mmol] |
Mass/Volume |
| 631618 |
77.083 |
1.000 |
0.500 |
38.542 mg |
| 134816 |
210.232 |
1.000 |
0.500 |
105.116 mg |
| 120207 |
181.235 |
1.074 |
0.550 |
92.811 µl |
| 10040989 |
172.187 |
1.000 |
0.500 |
86.094 mg |
| Acetic acid |
60.052 |
1.000 |
33.305 |
2000.000 µl |
| Product 1 |
526.640 |
1.000 |
0.500 |
263.320 µl |
Keywords
Heterocyclic, Multicomponent
Comments
Synthesis: In this synthesis of a tetrasubstituted tetrazole, a by-product can be formed. That is a tri-substituted tetrazole lacking the amine component.
Work-up: After the reaction, water was added to the reaction mixture in an attempt to get the product to crystallize. Instead, excess of the diketo compound (starting material) precipitated, which was filtered off.
Purification: The product was purified by preparative RP-LCMS.
Instrument Settings
Absorption level: Normal
Pre-stirring time: 0s
References
Usyatinsky, A. Y.; Khmelnitsky, Y. L. Tet. Lett. 2000, 41, 5031-5034
Balalaie, S.; Arabanian, A. Green Chem. 2000, 2, 274-276
Analysis
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0210071015_16A.pdf